Unlike many specific anti-wrinkle products that we look at here, Argireline is actually a patented peptide complex that is currently used as an ingredient by numerous beauty product manufacturers. Argireline, which goes under the scientific name of Acetyl Hexapeptide-3, is manufactured by Lipotec. Lipotec is a Barcelona-based cosmetics research lab. It is interesting to note that some of the products that feature Argireline as an active ingredient also sell themselves as made in the USA, neglecting the fact that Argireline’s real point of origin is in Europe.

So what’s so great about Argireline? The peptide is derived from natural proteins, and claims to actually relax facial muscles to the point of paralysis. This goes well with the company’s like Botox without the hassle claims. The theory guiding both products is that relaxed facial muscles will minimize current wrinkles caused by repetitive muscle contractions, as well as prevent new wrinkles. Muscle contractions are guided by a chemical reaction called the

SNAP receptor complex, and Argireline is specifically designed to interfere with this reaction.

With so many anti-wrinkle creams produced by multiple manufacturers all using Argireline, what’s the difference? For starters, different Argireline-based products use different concentrated solutions of the product. Despite what users might think, a higher concentration solution of Argireline may not be best. Lipotec’s own product trials show that a solution concentrated at 5 -10 percent has been most effective to date. Before buying an Argireline-based product, try to determine what concentration of the peptide is included. Although raw Argireline is available straight from Lipotec, it is only intended for industrial use and users should not try to formulate their own products at home.

Argireline can currently be found in creams, serums and eye creams. One caution about this peptide is that, like with many cutting edge technologies, long terms effects of consistent Argireline exposure have yet to be observed.

Argireline - Good Points

1] Available in many different products from many different manufacturers.
2] There is a lot of research available regarding this product.
3] Claims to mimic the muscle relaxing properties of Botox with topical application.

Argireline - Bad Points

1] Effects of long-term use are still unknown.
2] Lipotec, who conducted a lot of the quality research on Argireline, have no say regarding the products in which this peptide is used.
3] Not all Argireline products may feature the peptide in its ideal concentration.
4] Not available directly from manufacturer.


Argireline certainly seems to be a potent medicine. However, we’d be a bit more comfortable with it if we knew how it might effect skin in the long term.

That’s always a factor when looking at new cosmeceutical products. Additionally, the use of Argireline by third party product manufacturers is completely unregulated. We’ve seen some products that will use Lipotec’s Argireline testing data as a validation of their own creams and lotions. However, there is obviously no guarantee that these products are even including an ideal concentration of Argireline in its product, much less how the peptide will react with other included ingredients. There’s definitely a lot of miracle potential in Argireline, but we’d be sure to thoroughly research any product that features it before purchasing.

Argireline as an ingredient is used in cosmetic products including emulsions, gels, sera and others. The dosage recommended of Argireline is five percent or more, depending on many factors including the speed of wrinkle inhibition a person desires.

Some of the items used in wrinkle inhibition in the past have had long term health risks. That was one of the reasons for the development of Argireline.

Technically speaking Argireline was identified and developed for consumer use through an analysis of skin topography using adult female volunteers.

Argireline is thought by many researchers to inhibit neurotransmitter release with a potency much like other products used previously, but without the negative side effects.

Argireline is used in Revitol Skin Care Hydration Treatment Serum and Revitol Moisturizing Skin Treatment Cream. What exactly is Argireline? Argireline is a hexapeptide which is six naturally occurring amino acids in combination. It contains an active ingredient of acetyl hexapeptide 3 (AH3), known as a deep penetrating and powerful amino peptide. This active ingredient assists in relaxation of the intensity and frequency of contractions of facial muscles. The

result of this action is sometimes referred to as a "lifting" feeling. Argireline also seems to smooth skin through detour of the degeneration of collagen and elastin.

Many people, when using Argireline in cream form, use it around the yes, between the eyebrows, around the mouth and on the forehead, neck and the rest of the face. Researchers believe the results to be cumulative, and in some clinical studies a reduction in facial lines up to 17 percent occurred in a 15 day period, with up to 27 percent occurring in a 30 day period. These studies were performed with a five percent concentration of Argireline.

Beauty Products on our marketplace

Lachlan Walker has been reviewing natural and herbal skin care products such as Revitol Natural Skin Care through his network of herbal review websites such as HerbalWorks.